CA 125HE4 and ROME Algorithm – Major New Pillars in Ovarian Cancer Management

The ROME (Risk of Ovarian Malignancy Algorithm), allows the classification of patients in the category of high or low risk of detecting ovarian cancer during surgery of the ovarian mass.

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Combination of blood test and ROME algorithm receives FDA clearance to treat ovarian cancer.

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AETIOLOGY OF ENDOMETRIOSIS.VERY IMPORTANT
Endometriosis increases the risk of certain ovarian cancers
“Endometriosis is a disease equal to or more serious than breast cancer.
Transition between endometriosis and ovarian endometrioid carcinoma : Clinical and Research

Sainz de la Cuesta et al13 propose that the coexistence of endometrioid adenocarcinoma and endometriosis
Physicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis.
Tamoxifen and endometrial conditions in patients with breast cancer

Certain risk factors are associated with epithelial ovarian cancer. The following factors have been shown to increase a woman’s risk of ovarian cancer: Endometriosis

The prevalence of endometriosis in malignant epithelial ovarian tumors.
The prognosis of Japanese patients with clear cell carcinoma of the ovary associated with pelvic endometriosis: Clinico-pathological evaluation
Ovarian endometrioid adenocarcinoma derived from endometriosis in a young woman.
Histological transformation of benign endometriosis for early ovarian epithelial cancer.

Both malignant and borderline ovarian tumors are associated with ovarian endometriosis. In addition, atypical endometriosis was found to be associated with endometrioid and mixed epithelial ovarian tumors.
Carcinoma was a common associated finding in patients with ovarian endometriosis

Endometriosis increases the risk of three types of ovarian cancer
Tamoxifen, a hormone therapy, stimulates the growth of endometrial cells. This can cause endometriosis and also increase the risk of endometrial cancer